Publications Related to FAST-MAG Trial
by FAST-MAG Investigators

Publications from the FAST-MAG Phase 3 Trial Award
FAST-MAG Pilot Trial
Los Angeles Prehospital Stroke Screen
Los Angeles Motor Scale
Neuroprotective Stroke Therapy

Abstract


 

Publications from the FAST-MAG Phase 3 Trial Award

Saver JL, for the FAST-MAG Investigators. The design and conduct of clinical trials in emergency settings. Society for Clinical Trials 29th Annual Meeting, St. Louis, MO, May 20, 2008.

Saver JL, for the FAST-MAG Investigators. Magnesium and cerebrovascular disease. Gordon Research Conference on Magnesium in biochemical processes and medicine. Ventura, CA, March 11, 2008.

Sanossian N, Starkman S, Liebeskind DS, Ali LK, Restrepo L, Hamilton S, Saver JL, FAST-MAG Trial Investigators. Simultaneous ring, voice-over-internet phone system enables rapid physician elicitation of informed consent in prehospital stroke trials (abstract). Stroke 2008;39:708.

Yanes A, Haley T, Pierce B, Gordon M, Filip B, Lee M, Cho M, Starkman S, Saver J, on behalf of FAST MAG Investigators and Staff. Breaking traditional study time barriers: A descriptive review of demographic variables and unique early observations seen in a prehospital stroke study (abstract). Stroke 2008;39:590.

Saver JL, Eckstein M, Stratton S, Hamilton S, Conwit R, Liebeskind D, Sung G, Starkman S, for the FAST-MAG Investigators. The Field Administration of Stroke Therapy – Magnesium (FAST-MAG) Phase 3 Clinical Trial. Ongoing Clinical Trial Poster Session Abstract Book, International Stroke Conference 2008, New Orleans, LA, February 20, 2008.

Saver, J.L. How to select among endpoint analytic techniques for acute stroke clinical trials: Treatment effects for which shift analysis improves study power. Neurology 2007;68 (Suppl 1); A284.

Saver JL, Eckstein M, Stratton S, Hamilton S, Conwit R, Kidwell CS, Liebeskind D, Sung G, Starkman S, for the FAST-MAG Investigators. The Field Administration of Stroke Therapy – Magnesium (FAST-MAG) Phase 3 Clinical Trial. Ongoing Clinical Trial Poster Session Abstract Book, International Stroke Conference 2007, San Francisco, CA, February 16, 2007.

Saver JL, Starkman S, Eckstein M, Hamilton S, Kidwell CS, Stratton S, Conwit R, Liebeksind D, Sung G. FAST-MAG Investigators, Hyperacute prehospital stroke trial patients: Insights from the first 180 patients enrolled in the FAST-MAG Phase 3 Trial (abstract) Stroke 2007;38:499.

Saver JL, American Stroke Association. Food and Drug Administration public hearing on the conduct of emergency clinical research: testimony of the American Stroke Association. Academic Emergency Medicine 2007;14:e57-8.

Stewart D, Marder VJ, Starkman S, Saver JL. Magnesium sulfate neither potentiates nor inhibits tissue plasminogen activator induced thrombolysis. J Thromb Haemost 2006; 4: 1575–9.

Saver JL. Time is brain--quantified. Stroke 2006;37:263-6.

Starkman S, for the FAST-MAG Investigators. Magnesium as therapy for acute stroke: IMAGES and FAST-MAG trials. 11th International Magnesium Symposium, Kashikojima, Japan. October 26, 2006.

Saver JL, Starkman S, Eckstein M, Stratton S, Hamilton S, Radziszewska B, Kidwell CS, Liebeskind D, Sung G, Cohen SN, Starkman S, for the FAST-MAG Investigators. The Field Administration of Stroke Therapy – Magnesium (FAST-MAG) Phase 3 Clinical Trial. Ongoing Clinical Trial Poster Session Abstract Book CTP 35, International Stroke Conference 2006, Kissimmee, FL, February 16, 2006.

Schlueter G, Nye PJ, Morales-Tatgenhorst D, Haley T, Fitzgerald MJ, Saver J, Starkman S, FAST-MAG Investigators. Redefining hyperacute: Delivering neuroprotectants within two hours of stroke symptom onset. Stroke 2006;37:750.

Haley T, Gaughran G, Ross L, Morales-Tatgenhorst D, Binning A, Nighswonger B. When minutes count: standardized education by clinical research nurses to expedite a rapid stroke treatment study. American Association of Critical-Care Nurses National Teaching Institute and Critical Care Exposition 2005 Proceedings Abstract Book, 2005.

Saver JL, for the FAST-MAG Investigators. FAST-MAG: Evaluating magnesium for stroke in the hyperacute time window. Gordon Research Conference on Magnesium in Biochemical Processes and Medicine, Ventura, CA, February 7, 2005.

Saver JL, Starkman S, Eckstein M, Kidwell CS, Hamilton S, Stratton S, Cohen SN, Radziszewska B, Sung G, for the FAST-MAG Investigators. The Field Administration of Stroke Therapy – Magnesium (FAST-MAG) Phase 3 Clinical Trial. Ongoing Clinical Trial Poster Session Abstract Book, International Stroke Conference 2005, New Orleans, LA, February 3, 2005.

Gaughran G, Ross L, Haley T, Fitzgerald M, Nye P, Pierce B, Starkman S, Saver J, for the FAST-MAG Investigators. Novel research nurse role in prehospital stroke trials: Initial experience in the Field Administration of Stroke Therapy – Magnesium Clinical Trial. Ongoing Clinical Trial Poster Session Abstract Book, International Stroke Conference 2005, New Orleans, LA, February 3, 2005.

Ross L, Yanes A, Nighswonger B, Fitzgerald MJ, Sanoff R, Gaughran G, Saver J, Haley T, Starkman S, Tone B, Kidwell C, Eckstein M (for the FAST-MAG Investigators). Role of emergency nurse research coordinators in prehospital trials. Journal of Emergency Nursing 2005;31:A16.

Saver JL, for the FAST-MAG Investigators. When time is brain: Design challenges and solutions for prehospital phase III trials for neuroemergencies. 15h Annual Spring Brain Conference, Abstract Book, Sedona, AZ, March 2004.

Saver JL, Kidwell CS, Hamilton S, Eckstein M, Cohen SC, Radziszewska B, Sung G, Starkman S, for the FAST-MAG Investigators. The Field Administration of Stroke Therapy – Magnesium (FAST-MAG) Phase 3 Clinical Trial. Ongoing Clinical Trial Poster Session Abstract Book, 29th International Stroke Conference, San Diego, CA, February 5, 2004.


FAST-MAG Pilot Trial

Saver JL, Kidwell C, Eckstein M, Ovbiagele B, Starkman S, for the FAST-MAG Pilot Trial Investigators. Physician-investigator phone elicitation of consent in the field: a novel method to obtain explicit informed consent for prehospital clinical research. Prehospital Emergency Care 2006;10:182-5.

Saver JL, Kidwell C, Eckstein M, Starkman S, for the FAST-MAG Pilot Trial Investigators. Prehospital neuroprotective therapy for acute stroke: results of the Field Administration of Stroke Therapy – Magnesium (FAST-MAG) Pilot Trial. Stroke 2004;35:e106-e108. (DOI: 10.1161/01.STR.0000124458.98123.52)

Saver JL, Kidwell CS, Eckstein M, Starkman S, FAST-MAG Pilot Trial Investigators. High accuracy of LAPSS-guided paramedic selection of stroke patients for field-delivery of neuroprotective therapy. Stroke 2003;34:279A.


Los Angeles Prehospital Stroke Screen

Moftakhar P, Colby D, Starkman S, Saver JL, UCLA Student Stroke Team. The accuracy of prehospital stroke identification instruments: prospective comparison of the LAPSS, CPSS, and ELAPSS (abstract). Stroke 2008;39:574.

Saver JL, Kidwell CS, Eckstein M, Starkman S. Emerging applications of the Los Angeles Prehospital Stroke Screen (LAPSS), a validated tool for prehospital stroke recognition. The Stroke Interventionalist 2001;2(3):6-7.

Kidwell CS, Starkman S, Eckstein M, Weems K, Saver JL. Identifying stroke in the field: prospective validation of the Los Angeles Prehospital Stroke Screen (LAPSS). Stroke 2000;31:71-76.

Kidwell CS, Saver JL, Schubert GB, Eckstein M, Starkman S. Design and retrospective analysis of the Los Angeles Prehospital Stroke Screen (LAPSS). Prehospital Emergency Care 1998;2:267-273.


Los Angeles Motor Scale

Nazliel B, Starkman S, Liebeskind DS, Ovbiagele B, Kim D, Sanossian N, Ali L, Buck B, Villablanca P, Vinuela F, Duckwiler G, Jahan R, Saver JL. A brief prehospital stroke severity scale identifies ischemic stroke patients harboring persisting large arterial occlusions. Stroke 2008 Aug;39:2264-7.

Llanes JN, Kidwell CS, Starkman S, Leary MC, Eckstein M, Saver JL. The Los Angeles Motor Scale (LAMS): A new measure for characterizing stroke severity in the field. Prehospital Emergency Care 2004;8:46-50.

Ferguson KN, Kidwell CS, Starkman S, Eckstein M, Saver JL. Inter-rater and intra-rater reliability of the Los Angeles Motor Scale (LAMS), a prehospital measure of stroke severity. Stroke 2002;33:384.


Neuroprotective Stroke Therapy

Ovbiagele B, Kidwell CS, Starkman S, Saver JL. Neuroprotective agents for the treatment of acute ischemic stroke. Current Neurology and Neuroscience Reports 2003;3:9-20.

Ferguson KN, Kidwell CS, Starkman S, Saver JL. Hyperacute treatment initiation in neuroprotective stroke trials. Neurology 2002;58(suppl 3):A387.

Kidwell CS, Liebeskind DS, Starkman S, Saver JL. Trends in ischemic stroke trials through the 20th century. Stroke 2001;32:1349-1359.

Liebeskind DS, Kidwell CS, Saver JL. Meta-analysis of acute stroke trials employing neuroprotective agents. Neurology 1998;50:A346.

Abstracts

Saver JL, Kidwell CS, Hamilton S, Eckstein M, Cohen SC, Radziszewska B, Sung G, Starkman S, for the FAST-MAG Investigators. The Field Administration of Stroke Therapy – Magnesium (FAST-MAG) Phase 3 Clinical Trial. Ongoing Clinical Trial Poster Session Abstract Book, 29th International Stroke Conference, San Diego, CA, February 5, 2004. 

Saver JL, for the FAST-MAG Investigators. When time is brain: Design challenges and solutions for prehospital phase III trials for neuroemergencies. 15h Annual Spring Brain Conference, Abstract Book, Sedona, AZ, March 2004. 

Ross L, Yanes A, Nighswonger B, Fitzgerald MJ, Sanoff R, Gaughran G, Saver J, Haley T, Starkman S, Tone B, Kidwell C, Eckstein M (for the FAST-MAG Investigators). Role of emergency nurse research coordinators in prehospital trials. Journal of Emergency Nursing 2005;31:A16. 

Gaughran G, Ross L, Haley T, Fitzgerald M, Nye P, Pierce B, Starkman S, Saver J, for the FAST-MAG Investigators. Novel research nurse role in prehospital stroke trials: Initial experience in the Field Administration of Stroke Therapy – Magnesium Clinical Trial. Ongoing Clinical Trial Poster Session Abstract Book, International Stroke Conference 2005, New Orleans, LA, February 3, 2005. 

Saver JL, Starkman S, Eckstein M, Kidwell CS, Hamilton S, Stratton S, Cohen SN, Radziszewska B, Sung G, for the FAST-MAG Investigators. The Field Administration of Stroke Therapy – Magnesium (FAST-MAG) Phase 3 Clinical Trial. Ongoing Clinical Trial Poster Session Abstract Book, International Stroke Conference 2005, New Orleans, LA, February 3, 2005. 

Saver JL, for the FAST-MAG Investigators. FAST-MAG: Evaluating magnesium for stroke in the hyperacute time window. Gordon Research Conference on Magnesium in Biochemical Processes and Medicine, Ventura, CA, February 7, 2005. 

Haley T, Gaughran G, Ross L, Morales-Tatgenhorst D, Binning A, Nighswonger B. When minutes count: standardized education by clinical research nurses to expedite a rapid stroke treatment study. American Association of Critical-Care Nurses National Teaching Institute & Critical Care Exposition 2005 Proceedings Abstract Book, 2005. 

Schlueter G, Nye PJ, Morales-Tatgenhorst D, Haley T, Fitzgerald MJ, Saver J, Starkman S, FAST-MAG Investigators. Redefining hyperacute: Delivering neuroprotectants within two hours of stroke symptom onset. Stroke 2006;37:750. 

Saver JL, Starkman S, Eckstein M, Stratton S, Hamilton S, Radziszewska B, Kidwell CS, Liebeskind D, Sung G, Cohen SN, Starkman S, for the FAST-MAG Investigators. The Field Administration of Stroke Therapy – Magnesium (FAST-MAG) Phase 3 Clinical Trial. Ongoing Clinical Trial Poster Session Abstract Book CTP 35, International Stroke Conference 2006, Kissimmee, FL, February 16, 2006. 

Starkman S, for the FAST-MAG Investigators. Magnesium as therapy for acute stroke: IMAGES and FAST-MAG trials. 11th International Magnesium Symposium, Kashikojima, Japan. October 26, 2006.

Saver JL, Eckstein M, Stratton S, Hamilton S, Conwit R, Kidwell CS, Liebeskind D, Sung G, Starkman S, for the FAST-MAG Investigators. The Field Administration of Stroke Therapy – Magnesium (FAST-MAG) Phase 3 Clinical Trial. Ongoing Clinical Trial Poster Session Abstract Book, International Stroke Conference 2007, San Francisco, CA, February 16, 2007. 

Saver JL, Starkman S, Eckstein M, Hamilton S, Kidwell CS, Stratton S, Conwit R, Liebeksind D, Sung G. FAST-MAG Investigators, Hyperacute prehospital stroke trial patients: Insights from the first 180 patients enrolled in the FAST-MAG Phase 3 Trial (abstract) Stroke 2007;38:499. 

Saver JL, Eckstein M, Stratton S, Hamilton S, Conwit R, Liebeskind D, Sung G, Starkman S, for the FAST-MAG Investigators. The Field Administration of Stroke Therapy – Magnesium (FAST-MAG) Phase 3 Clinical Trial. Ongoing Clinical Trial Poster Session Abstract Book, International Stroke Conference 2008, New Orleans, LA, February 20, 2008. 

Yanes A, Haley T, Pierce B, Gordon M, Filip B, Lee M, Cho M, Starkman S, Saver J, on behalf of FAST MAG Investigators and Staff.  Breaking traditional study time barriers: A descriptive review of demographic variables and unique early observations seen in a prehospital stroke study (abstract). Stroke 2008;39:590.

Sanossian N, Starkman S, Liebeskind DS, Ali LK, Restrepo L, Hamilton S, Saver JL, FAST-MAG Trial Investigators.  Simultaneous ring, voice-over-internet phone system enables rapid physician elicitation of informed consent in prehospital stroke trials (abstract). Stroke 2008;39:708.

Saver JL, for the FAST-MAG Investigators. Magnesium and cerebrovascular disease. Gordon Research Conference on Magnesium in biochemical processes and medicine. Ventura, CA, March 11, 2008.

Saver JL, for the FAST-MAG Investigators. The design and conduct of clinical trials in emergency settings. Society for Clinical Trials 29th Annual Meeting, St. Louis, MO, May 20, 2008.

 

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